Jacob Miles, Ariana Simps, Simon Keller
Virchow Robin Spaces (VRS), perivascular spaces surrounding cerebral blood vessels, facilitate fluid exchange between blood, cerebrospinal fluid, and interstitium. Enlarged VRS are common in both health and disease, with evidence suggesting associations with cardiovascular risk factors. However, their contribution to disease pathogenesis remains unclear. Limited evidence links enlarged VRS to clinical measures of disease severity across various neurological conditions.
In Multiple Sclerosis (MS), while some studies suggest associations with lesion volume and disease severity, a meta-analysis failed to replicate these findings, indicating the limited utility of VRS as diagnostic or prognostic markers. Methodological limitations in VRS identification and quantification challenge the strength of these associations. Future research should focus on refined quantification methods to better understand the role of VRS in neurological diseases.