Mohamed Irfan
Alzheimer's Disease (AD)-related cognitive impairment and dementia have been linked to a variety of genetic, environmental, and lifestyle variables. When investigating preventative or ameliorative interventions aimed at dementia and its preclinical stages, a variety of potentially modifiable risk variables should be taken into account. This study looked into the relationship between two such potentially modifiable risk factors —Bone Mineral Density (BMD) and body composition—and cognitive impairment. For this longitudinal study, 164 patients were enrolled, who were tested cognitively and clinically at baseline and three years later. Their ages ranged from 34 to 87 .
Dual Energy X-Ray Absorptiometry (DXA) was performed on the same day as the cognitive assessment, and blood samples were taken for Apolipoprotein E (APOE) genotyping. We discovered through hierarchical regression analysis that BMD and lean body mass, as determined by DXA, were important predictors of episodic memory. Premorbid IQ, APOE status, age, and gender were taken into account. Particularly, BMD and lean mass were substantially correlated with List A learning from the California Verbal Learning Test at both the baseline and follow-up assessments. Our results show a substantial relationship between BMD, lean body mass, and episodic linguistic learning.