Antonino Araco
Introduction: Autologous fat had been used as filler
in various augmentation and contour correction procedures
by using the lipofilling property of adipocytes.
In 2001, Zuk et al. introduced multipotent progenitor
cells called adipose-derived stem cells (ADSCs), which
are present as stromal vascular fraction and CD34+ subfraction.
The study of Tonnard et al. in 2013 had proven
that mechanically emulsified autologous fat also called
as nanofat retains the regenerative potential because it is
rich in adipose-derived stem cells (ADSCs) and Stromal
vascular fraction (SVF). These cells act through paracrine
signaling by synthesizing immunosuppressive and pro-angiogenic
factors. They are of key importance with regard
to the regenerative properties of autologously grafted adipose
tissue (AT).