Tang, J. Orexin Signaling System-Potential Therapeutic Targets for Alzheimer's Disease and Various Mental Diseases. J Neuro Neurophysiol 2023, 14(7), 001-008
Background: Orexin (Orexin), also known as hypothalamic secretin (Hypocretin), is an important central neuropeptide involved in many physiological processes in the body, such as the regulation of diet behaviour, sleep-wake cycles and learning and memory functions. In the nervous system, orexin defects can cause narcolepsy. Other studies have shown that orexin is involved in emotional changes, reward behaviour, adaptation, stress, stress response and a series of body behaviour responses.
Objective: To summarize the physiological function of orexin. This study provides new ideas for the diagnosis and treatment of Alzheimer's disease and other diseases.
Conclusion: Orexin can not only treat sleep-wake disorders in Alzheimer's disease but also in narcolepsy, depression and addiction.