Jonathan Bells
Neurological disorders cover a wide range of illnesses, including those that appear early in development, progress slowly, or become apparent as people age. Despite the fact that the underlying causes of these disorders are distinct, the activation of shared pathways such as the Integrated Stress Response (ISR) and the emergence of shared phenotypes (sleep deficits) may provide information about some of the mechanistic underpinnings of neurologic dysfunction. Despite its complexity, the relationship between sleep and ongoing stress in the brain has enormous implications for understanding neurological illnesses ranging from development to degeneration. The convergent nature of the ISR may serve as a link between genetically distinct neurological illnesses by disrupting a critical cellular homeostasis route.