R. Rajakumari
Proanthocyanidins (PCs), a component of grape seed extract (GSE), has recently being used for the treatment of wounds. Proanthocyanidins, the principal component of GSE, has recently been identified as a main mediator of GSE medicinal properties. We present here an approach for manufacturing PCs/soluplus (SOLU) blended nanodispersion prepared by freeze drying technique to adequately enhance the stability and bioavailability of the PCs for wound repair. The PCs/SOLU nanodispersion (0.5, and 1.5 g) was incorporated into 10 g of a simple ointment base by melting and trituration to give two batches of the ointment formulation which could be easily applied topically to wounds.