药物科学与药物开发杂志

Antibodies with Functionality as a New Generation of Translational Tools designed to be programmed via translational resources to predict and to prevent Demyelination

Sergey Suchkov

Abs against myelin basic protein/MBP endowing with proteolytic
activity (Ab-proteases with functionality) are of great value
to monitor demyelination to illustrate the evolution of multiple
sclerosis (MS). Anti-MBP autoAbs from MS patients and
mice with EAE exhibited specific proteolytic cleavage of MBP
which, in turn, markedly differed between: (i) MS patients and
healthy controls; (ii) different clinical MS courses; (iii) EDSS
scales of demyelination to correlate with the disability of MS
patients to predict the transformation prior to changes of the
clinical course.