Kam Tim Michael Chan, Ching Yi Hui and Matthew Ming Wai Ma
Porokeratosis is a pre-malignant skin condition with a great variety of types and clinical presentation. Delay diagnosis and treatment is common as the asymptomatic lesion may easily un-noticed by the attended especially in a hectic clinic setting. Untreated, large porokeratosis may develop into squamous cell carcinoma and metastasize especially in the chronic immunosuppressed. We reported a case of a female middle-aged lady who presented with a thirty years history of porokeratosis of Mebelli satisfactorily managed by topical imiquimod after sixteen weeks duration with complete clearance. Wounds and ulcerations are a significant downtime during therapy.